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Fig. 3 | Virology Journal

Fig. 3

From: Substitution of amino acid residue V1213 in the helicase domain of the genotype 3 hepatitis E virus reduces virus replication

Fig. 3

Relative luciferase activities in Huh7 S10–3 liver cells transfected with RNA of HEV genotype 3 Rluc mutants containing S605P + I978V, and V1213A mutations. S605P + I978V: pHEV3-RLuc contains mutations of S605P and I978V; S605P + I978V + V1213A: pHEV3-RLuc contains mutations of S605P, I978V and V1213A. The error bars indicate standard deviations (SD). The differences of relative luciferase activity produced by mutants of HEV Rluc replicons and the wild-type HEV Rluc replicon were compared by one-way analysis of variance (ANOVA) using the Kruskal-Wallis test (P < 0.05). Asterisks (*) indicate statistical differences compared to the parental wild-type HEV replicons, *, P < 0.05; ***, P < 0.001

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