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Fig. 2 | Virology Journal

Fig. 2

From: Substitution of amino acid residue V1213 in the helicase domain of the genotype 3 hepatitis E virus reduces virus replication

Fig. 2

Effect of mutation at amino acid residue 1213 on genotype 1 and genotype 3 HEV replicons. a A1213V mutation on genotype 1 HEV EGFP replicon. HEV2, pSKHEV2-EGFP replicon; HEV2 A1213V, pSKHEV2-EGFP replicon with mutation A1213V. b V1213A mutation on genotype 3 HEV EGFP replicon. HEV3, pSHEV3-EGFP replicon; HEV3 V1213A, pSHEV3-EGFP replicon with mutation V1213A. c A1213V mutation on genotype 1 HEV luciferase replicon. HEV2Rluc, pSKHEV2-Rluc replicon; HEV2Rluc A1213V, pSKHEV2-Rluc replicon with mutation A1213V. d V1213A mutation on genotype 3 HEV luciferase replicon. HEV3Rluc, pSHEV3-Rluc replicon; HEV3Rluc V1213A, pSHEV3-Rluc replicon with mutation V1213A. The error bars indicate standard deviations (SD). The differences of RLU produced by HEV Rluc mutants and the wild-type Rluc replicon were compared by t-test. Asterisks (*) indicate statistical differences compared to the wild-type HEV replicons. *, P < 0.05; ***, P < 0.001

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