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Table 1 Demographics and baseline disease characteristics

From: A 3-year follow-up study after treatment with simeprevir in combination with pegylated interferon-α and ribavirin for chronic hepatitis C virus infection

  SVR at LPVPS No SVR at LPVPS
N = 200 Eligible
N = 294
Enrolled
N = 49
Age, years; median (range) 52.0 (22–70) 53.0 (19–71) 56.0 (28–70)
  ≤ 45 years, n (%) 61 (30.5) 64 (21.8) 7 (14.3)
  > 45 − ≤ 65 years, n (%) 133 (66.5) 218 (74.1) 38 (77.6)
  > 65 years, n (%) 6 (3.0) 12 (4.1) 4 (8.2)
Male, n (%) 122 (61.0) 196 (66.7) 32 (65.3)
Ethnicity, n (%)
 Hispanic or Latino 7 (3.5) 35 (11.9) 5 (10.2)
Race, n (%)a
 White 187 (93.5) 268 (91.2) 44 (89.8)
 Black/African American 8 (4.0) 21 (7.1) 4 (8.2)
 American Indian/Alaskan native 1 (0.5) 0 0
 Asian 4 (2.0) 3 (1.0) 1 (2.0)
 Native Hawaiian or other Pacific islander 0 2 (0.7) 0
IL28B genotype, n/N (%)b
 CC 10/34 (29.4) 9/143 (6.3) 0
 CT 19/34 (55.9) 99/143 (69.2) 17/20 (85.0)
 TT 5/34 (14.7) 35/143 (24.5) 3/20 (15.0)
Prior response, n (%)a
 Naïve 50 (25.0) 138 (46.9) 15 (30.6)
 Null responder 26 (13.0) 46 (15.6) 12 (24.5)
 Partial responder 48 (24.0) 38 (12.9) 9 (18.4)
 Relapser 76 (38.0) 72 (24.5) 13 (26.5)
Baseline HCV RNA, log10 IU/mL; median (range)a 6.44 (3.5–7.5) 6.62 (4.9–7.6) 6.76 (5.6–7.5)
LPVPS HCV RNA, log10 IU/mL; median (range) a,c 0.95 (1.0–1.0) 6.35 (3.2–7.4) 6.35 (3.2–7.4)
HCV geno/subtypea
 1a/other 68 (34.0) 174 (59.2) 25 (51.0)
  with Q80K 21 (30.9) 79 (45.4) 10 (40.0)
 1b 132 (66.0) 120 (40.8) 24 (49.0)
METAVIR fibrosis score; n/N (%)a,d
 F0, 1 or 2 152/199 (76.4) 156/290 (53.8) 27/49 (55.1)
 F3 26/199 (13.1) 76/290 (26.2) 8/49 (16.3)
 F4 21/199 (10.6) 58/290 (20.0) 14/49 (28.6)
  1. HCV hepatitis C virus, IL28B interleukin-28b, LPVPS last post-therapy follow-up visit of the parent study, SVR sustained virologic response
  2. aObtained from the parent study
  3. bResults obtained from the central laboratory in parent study; data not available for patients from the PILLAR and ASPIRE studies
  4. cUndetectable HCV RNA is imputed with 9 IU/mL (log10[9] = 0.95)
  5. dMETAVIR score was not available for one patient