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Fig. 2 | Virology Journal

Fig. 2

From: A 3-year follow-up study after treatment with simeprevir in combination with pegylated interferon-α and ribavirin for chronic hepatitis C virus infection

Fig. 2

Emerging NS3 amino acid substitutions at time of failure in simeprevir Phase IIb/III studies. Considering emerging amino acid substitutions at 18 NS3 positions of interest: 36, 41, 43, 54, 55, 80, 107, 122, 132, 138, 155, 156, 158, 168, 169, 170, 174 and 175. One patient had no sequencing data available. *Amino acid substitutions in patients with Q80K at baseline. #1: R155K or Q + D168E/V or A/V or S122R or G + R155K or D168A, includes one patient with I132L + R155K + D168E + N174G; #2: includes one patient with V132I + D168V. #3: includes one patient with V36M + R155K; #4: alone or in combination with I132L*, I170T* or N174S*

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