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Table 2 Pairs of interacting DE miRNAs and predicted target mRNAs (TLR and RLR signalling pathways) in PCMV-infected thymus

From: MicroRNA transcriptome analysis of porcine vital organ responses to immunosuppressive porcine cytomegalovirus infection

miRNAs miRNA expression level PCMV infected vs. control Log2 (Fold change) miRNA target Genes Target mRNA expression level PCMV infected vs. control Log2 (Fold change value) Target gene related signaling pathways
miR-10a-5p +2.53 TLR6 −2.88 Toll-like receptor signaling pathway
miR-10a-5p +2.53 TLR7 −2.01 Toll-like receptor signaling pathway
miR-27b-3p +4.84 PIK3CG −2.77 Toll-like receptor signaling pathway
miR-27b-3p +4.84 JAK2 −2.15 Toll-like receptor signaling pathway
miR-27b-3p +4.84 DHX58 −4.95 RIG-I-like receptor signaling pathway
miR-30a-5p +3.99 CXCL9 −3.93 Toll-like receptor signaling pathway
miR-30a-5p +3.99 IL12B −4.2 Toll-like receptor signaling pathway
miR-30a-5p +3.99 IL12B −4.2 RIG-I-like receptor signaling pathway
miR-30a-5p +3.99 MAP3K1 −3.03 RIG-I-like receptor signaling pathway
miR-30a-5p +3.99 TANK −2.09 RIG-I-like receptor signaling pathway
miR-143-3p +6.68 CD40 −4.97 Toll-like receptor signaling pathway
miR-143-3p +6.68 JAK3 −2.69 Toll-like receptor signaling pathway
miR-143-3p +6.68 DDX58 −4.44 RIG-I-like receptor signaling pathway
miR-143-3p +6.68 IKBKB −2.16 RIG-I-like receptor signaling pathway
miR-148a-3p +2.46 MAPK14 −3.77 Toll-like receptor signaling pathway
miR-148a-3p +2.46 STAT1 −2.67 Toll-like receptor signaling pathway
miR-148a-3p +2.46 STAT5B −2.55 Toll-like receptor signaling pathway
miR-148a-3p +2.46 DDX3X −2.94 RIG-I-like receptor signaling pathway
miR-novel-chr2_21624 +6.68 IKBKB −2.16 Toll-like receptor signaling pathway
miR-novel-chr2_21624 +6.68 MAP3K7 −3.96 Toll-like receptor signaling pathway
miR-novel-chr2_21624 +6.68 MAP3K7 −3.96 RIG-I-like receptor signaling pathway
miR-novel-chr2_21624 +6.68 MAPK14 −3.77 RIG-I-like receptor signaling pathway
  1. “+” and “–” indicate upregulated and downregulated miRNAs or mRNAs, respectively. The fold change cutoffs of the upregulated miRNAs and the downregulated miRNAs or mRNAs were +2 and −0.5, respectively