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Fig. 5 | Virology Journal

Fig. 5

From: Enhanced human enterovirus 71 infection by endocytosis inhibitors reveals multiple entry pathways by enterovirus causing hand-foot-and-mouth diseases

Fig. 5

The effect of CPZ on EV71 infection after depletion of CME. a. A549 and RD cells were transfected with vary siRNA or scramble siRNA for 96 h. Then cells were infected with EV71 at an MOI of 1 in the presence of 20 μM CPZ or DMSO for 24 h (A549) or 6 h (RD). Flow cytometry was applied to determine the viral infectivity. The representative percentages of the infected cells were indicated. b. The bar plots showed the summary of three independent experiments. The significance was determined by paired Student’s t test by comparing CPZ treatment to DMSO control (A549) or gene-knockdown group to scramble group (RD). *p < 0.05; **p < 0.01

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