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Fig. 5 | Virology Journal

Fig. 5

From: Pulmonary edema following central nervous system lesions induced by a non- mouse-adapted EV71 strain in neonatal BALB/c mice

Fig. 5

Representative histology of various tissues of ZZ1350-infected mice. Three-day-old BALB/c mice were intracerebral, intramuscular, intraperitoneal inoculated with ZZ1350 strain (2 × 106 PFU/mouse), and histopathological changes of tissues from mice were examined at 7 dpi as described in Materials and Methods. Solid yellow arrows: severe necrotizing myositis with fragmentation of myofibers and inflammatory cells infiltration; Solid red arrows: myocarditis with inflammatory cells infiltration or cardiomyocytes necrosis; hollow black arrows: inflammatory cells infiltration; hollow yellow arrows: erythrocyte aggregation; hollow red arrows: villous atrophy with edema fluid accumulation in the lumen

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