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Table 2 Steady state data for filibuvir interacting with immobilized NS5B, and effect of AnxA2 on the interaction

From: Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition

Surface K D app ± SE (nM) Rmax ± SE (RU)
NS5Ba 160 ±20 39 ± 1.0
NS5Bb 250 ± 30 33 ± 0.7
NS5B pre-injected with AnxA2 390 ± 54 16 ± 0.6
  1. aActivated and inactivated blank reference surface
  2. bInactivated NS5B reference surface. SE = standard error. Data from Fig. 2a and b