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Table 2 Steady state data for filibuvir interacting with immobilized NS5B, and effect of AnxA2 on the interaction

From: Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition

Surface

K D app ± SE

(nM)

Rmax ± SE

(RU)

NS5Ba

160

±20

39

± 1.0

NS5Bb

250

± 30

33

± 0.7

NS5B pre-injected with AnxA2

390

± 54

16

± 0.6

  1. aActivated and inactivated blank reference surface
  2. bInactivated NS5B reference surface. SE = standard error. Data from Fig. 2a and b
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Virology Journal

ISSN: 1743-422X