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Fig. 4 | Virology Journal

Fig. 4

From: Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition

Fig. 4

Interaction between the 8-mer RNA and AnxA2. The 8-mer RNA was injected at 3 to 100 nM over a immobilized AnxA2 (3595 RU) and b immobilized mAnxA2 (1041 RU). All sensorgrams were corrected for unspecific binding by blank and reference surface subtraction. An activated and inactivated surface was used as a reference. c) Non-linear regression analysis of the SPR sensorgram in (a) using a reversible 1-step 1:1 model. d Steady state analysis of report points taken at the end of the injections in (a). Vertical lines on steady-state analysis plots indicate KD values

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