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Fig. 3 | Virology Journal

Fig. 3

From: The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis

Fig. 3

Expression of CCR8 in JPX9 T-cells and peripheral blood mononuclear cells (PBMCs) from HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. The levels of CCR8 expression in HTLV-1-infected and -uninfected human T-cell lines as well as in PBMCs derived from HAM/TSP patients were examined using flow cytometry. a. CCR8 was expressed in both HTLV-1-infected and -uninfected T-cell lines, but the mean fluorescence intensities (MFIs) of these T-cell lines were not associated with the status of HTLV-1 infection. b. The MFI of CCR8 was higher in the Tax-positive fraction compared to the Tax-negative fraction in Tax-induced JPX-9 cells c. The MFI of CCR8 was higher in Tax-positive PBMCs than Tax-negative PBMCs derived from HAM/TSP patients

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