Haplotypea
| Group A(%) | Group B(%) | Group C(%) | Group (A + B)/Group C | Group A/Group B |
---|
n = 740 |
n = 388 |
n = 1946 | ORb
|
P
b
| ORc
|
P
c
|
---|
GG | 345 (46.6) | 191 (49.2) | 929 (47.7) | 1.00 | 1.00 | 1.00 | 1.00 |
GA | 39 (5.3) | 21 (5.4) | 92 (4.7) | 1.07 (0.74–1.54) | 0.712 | 0.86 (0.48–1.56) | 0.628 |
AG | 269 (36.4) | 130 (33.5) | 733 (36.7) | 0.93 (0.78–1.10) | 0.390 | 1.18 (0.88–1.58) | 0.278 |
AA | 87 (11.8) | 46 (11.9) | 192 (9.9) |
1.37 (1.05–1.78)
|
0.018
| 1.09 (0.71–1.66) | 0.698 |
- Group A: chronic HCV infection; Group B: spontaneous HCV clearance; Group C: non-HCV infection; Group (A + B): HCV-infected patients
-
Abbreviations: SNPs single nucleotide polymorphisms
- Bold type indicates statistically significant results
-
aOrder of single nucleotide polymorphisms comprising the HLA class II haplotypes: s9277535 and rs7453920
-
bThe P value, OR and 95% CIs of group (A + B) versus Group C were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, and high-risk population
-
cThe P value, OR and 95% CIs of group A versus Group B were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, high-risk population, and HCV genotypes