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Table 4 Haplotypes analysis of rs9277535 and rs7453920 with different HCV outcomes

From: The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population

Haplotypea Group A(%) Group B(%) Group C(%) Group (A + B)/Group C Group A/Group B
n = 740 n = 388 n = 1946 ORb P b ORc P c
GG 345 (46.6) 191 (49.2) 929 (47.7) 1.00 1.00 1.00 1.00
GA 39 (5.3) 21 (5.4) 92 (4.7) 1.07 (0.74–1.54) 0.712 0.86 (0.48–1.56) 0.628
AG 269 (36.4) 130 (33.5) 733 (36.7) 0.93 (0.78–1.10) 0.390 1.18 (0.88–1.58) 0.278
AA 87 (11.8) 46 (11.9) 192 (9.9) 1.37 (1.05–1.78) 0.018 1.09 (0.71–1.66) 0.698
  1. Group A: chronic HCV infection; Group B: spontaneous HCV clearance; Group C: non-HCV infection; Group (A + B): HCV-infected patients
  2. Abbreviations: SNPs single nucleotide polymorphisms
  3. Bold type indicates statistically significant results
  4. aOrder of single nucleotide polymorphisms comprising the HLA class II haplotypes: s9277535 and rs7453920
  5. bThe P value, OR and 95% CIs of group (A + B) versus Group C were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, and high-risk population
  6. cThe P value, OR and 95% CIs of group A versus Group B were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, high-risk population, and HCV genotypes