Skip to main content

Table 3 Stratified analysis the association of HLA-DP/DQ with HCV susceptibility and chronicity

From: The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population

SNP

Subgroups

Group(A + B)/Group C

Group A/Group B

ORa

P a

ORb

P b

rs9277535

Age

 <50

1.02(0.74–1.42)

0.901

1.71(1.02–2.86)

0.042

 ≥50

1.01(0.69–1.47)

0.965

1.29(0.64–2.57)

0.475

High-risk population

 Drug user

0.92(0.58–1.47)

0.733

2.19(0.94–5.11)

0.069

 HD

1.35(0.89–2.04)

0.162

0.87(0.42–1.81)

0.700

 PBD

0.93(0.60–1.45)

0.746

1.94(1.04–3.63)

0.037

rs7453920

Age

 <50

1.42(1.02–1.98)

0.040

0.82(0.49–1.37)

0.445

 ≥50

1.21(0.82–1.78)

0.329

1.23(0.58–2.58)

0.591

High-risk population

 Drug user

1.36(0.83–2.22)

0.218

1.22(0.45–3.32)

0.693

 HD

1.53(1.04–2.25)

0.029

1.02(0.51–2.01)

0.962

 PBD

1.20(0.75–1.93)

0.449

0.83(0.43–1.60)

0.572

  1. Group A: chronic HCV infection; Group B: spontaneous HCV clearance; Group C: non-HCV infection; Group (A + B): HCV-infected patients
  2. Abbreviations: HD, hemodialysis patient; PBD, paid blood donors
  3. Bold type indicates statistically significant results
  4. aThe P value, OR and 95% CIs of group (A + B) versus Group C were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, and high-risk population in dominant model (GG versus AG + AA for rs9277535 and rs7453920)
  5. bThe P value, OR and 95% CIs of group A versus Group B were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, high-risk population, and HCV genotypes in dominant model (GG versus AG + AA for rs9277535 and rs7453920)