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Table 3 Stratified analysis the association of HLA-DP/DQ with HCV susceptibility and chronicity

From: The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population

SNP Subgroups Group(A + B)/Group C Group A/Group B
ORa P a ORb P b
rs9277535 Age
 <50 1.02(0.74–1.42) 0.901 1.71(1.02–2.86) 0.042
 ≥50 1.01(0.69–1.47) 0.965 1.29(0.64–2.57) 0.475
High-risk population
 Drug user 0.92(0.58–1.47) 0.733 2.19(0.94–5.11) 0.069
 HD 1.35(0.89–2.04) 0.162 0.87(0.42–1.81) 0.700
 PBD 0.93(0.60–1.45) 0.746 1.94(1.04–3.63) 0.037
rs7453920 Age
 <50 1.42(1.02–1.98) 0.040 0.82(0.49–1.37) 0.445
 ≥50 1.21(0.82–1.78) 0.329 1.23(0.58–2.58) 0.591
High-risk population
 Drug user 1.36(0.83–2.22) 0.218 1.22(0.45–3.32) 0.693
 HD 1.53(1.04–2.25) 0.029 1.02(0.51–2.01) 0.962
 PBD 1.20(0.75–1.93) 0.449 0.83(0.43–1.60) 0.572
  1. Group A: chronic HCV infection; Group B: spontaneous HCV clearance; Group C: non-HCV infection; Group (A + B): HCV-infected patients
  2. Abbreviations: HD, hemodialysis patient; PBD, paid blood donors
  3. Bold type indicates statistically significant results
  4. aThe P value, OR and 95% CIs of group (A + B) versus Group C were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, and high-risk population in dominant model (GG versus AG + AA for rs9277535 and rs7453920)
  5. bThe P value, OR and 95% CIs of group A versus Group B were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, high-risk population, and HCV genotypes in dominant model (GG versus AG + AA for rs9277535 and rs7453920)