SNP | Subgroups | Group(A + B)/Group C | Group A/Group B |
---|
ORa
|
P
a
| ORb
|
P
b
|
---|
rs9277535 | Age |
<50 | 1.02(0.74–1.42) | 0.901 |
1.71(1.02–2.86)
|
0.042
|
≥50 | 1.01(0.69–1.47) | 0.965 | 1.29(0.64–2.57) | 0.475 |
High-risk population |
Drug user | 0.92(0.58–1.47) | 0.733 | 2.19(0.94–5.11) | 0.069 |
HD | 1.35(0.89–2.04) | 0.162 | 0.87(0.42–1.81) | 0.700 |
PBD | 0.93(0.60–1.45) | 0.746 |
1.94(1.04–3.63)
|
0.037
|
rs7453920 | Age |
<50 |
1.42(1.02–1.98)
|
0.040
| 0.82(0.49–1.37) | 0.445 |
≥50 | 1.21(0.82–1.78) | 0.329 | 1.23(0.58–2.58) | 0.591 |
High-risk population |
Drug user | 1.36(0.83–2.22) | 0.218 | 1.22(0.45–3.32) | 0.693 |
HD |
1.53(1.04–2.25)
|
0.029
| 1.02(0.51–2.01) | 0.962 |
PBD | 1.20(0.75–1.93) | 0.449 | 0.83(0.43–1.60) | 0.572 |
- Group A: chronic HCV infection; Group B: spontaneous HCV clearance; Group C: non-HCV infection; Group (A + B): HCV-infected patients
- Abbreviations: HD, hemodialysis patient; PBD, paid blood donors
- Bold type indicates statistically significant results
-
aThe P value, OR and 95% CIs of group (A + B) versus Group C were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, and high-risk population in dominant model (GG versus AG + AA for rs9277535 and rs7453920)
-
bThe P value, OR and 95% CIs of group A versus Group B were calculated on the basis of the binary logistic regression model, adjusted by gender, age, ALT, AST, high-risk population, and HCV genotypes in dominant model (GG versus AG + AA for rs9277535 and rs7453920)