TY - JOUR AU - Pisano, Gina AU - Roy, Arunava AU - Ahmed Ansari, Mairaj AU - Kumar, Binod AU - Chikoti, Leela AU - Chandran, Bala PY - 2017 DA - 2017/11/13 TI - Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency JO - Virology Journal SP - 221 VL - 14 IS - 1 AB - Epstein-Barr virus (EBV) exhibits both lytic and latent (Lat. I, II, and III) phases in an infected individual. It’s during the latent phase of EBV that all EBV-associated cancers, including Burkitt’s lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. Interferon-γ-inducible protein 16 (IFI16) is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading DNA viruses. During latency, IFI16 remains in the nucleus, in part bound to the EBV genome; however, neither its role in EBV lytic cycle or latency has been established. SN - 1743-422X UR - https://doi.org/10.1186/s12985-017-0891-5 DO - 10.1186/s12985-017-0891-5 ID - Pisano2017 ER -