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Table 3 Evolutionary coupling terms for covarying positions within the HIV-1 integrase

From: Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

position i

position j

ecij

6

10

0.0823

10

17

0.0623

10

72

0.1550

10

122

0.0994

11

17

0.0668

11

21

0.0847

11

24

0.0924

11

31

0.0883

11

111

0.0858

11

119

0.0995

11

154

0.0500

17

31

0.0516

17

119

0.0562

17

124

0.0755

23

201

0.0721

24

25

0.0717

24

45

0.0543

24

72

0.0554

28

39

0.0826

31

154

0.0362

39

154

0.0449

39

201

0.1201

39

256

0.0559

39

265

0.0411

45

160

0.0757

72

265

0.0897

101

111

0.0738

101

112

0.0677

101

154

0.0740

112

124

0.0567

112

201

0.0612

119

122

0.2792

124

125

0.0466

124

211

0.0589

154

165

0.1792

154

256

0.0488

154

265

0.0647

157

160

0.1177

201

256

0.0781

201

265

0.0641

219

222

0.0730

234

253

0.0679

  1. Evolutionary coupling terms ecij between position i and j with P < 0.005 and power > 0.95 are given