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Table 2 Overall frequency (%) of minor INSTI resistance mutations and INSTI-selected mutations

From: Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors

  Overall frequency (%) of
Variant minor INSTI resistance mutation INSTI-selected mutation
M50I   12.8
V54I 0.9  
G59E   2.1
L68V 1.2  
L74I 2.7  
L74 M 0.6  
L101I   36.8
S119R 3.0  
T122I   24.3
T124A 25.8  
T124 N   
T125A   17.8
A128T 0.9  
E138D   1.5
V151A 0.3  
V151I 7.4  
M154I   18.4
K156 N 5.3  
E157Q 2.4  
G163E   2.4
G163R 0.3  
V165I   
H171Q   
G193E   10.1
V201I   36.8
I203M   3.3
T206S 6.8  
N222 K   
S230G 0.6  
S230 N 8.0  
V260I 0.3