Fig. 1From: Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitorsRibbon model of the HIV-1 integrase monomer from two viewpoints. The model was constructed in PyMol [67] as an overlay of protein database structures 1ex4 [3] and 1k6y [4]. The NTD (aa 1–49) is coloured yellow, the CCD (aa 50–212) green, and the CTD (aa 213–288) red. Polymorphic sites are coloured greyBack to article page