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Table 1 Appearance of anti-HBc and anti-HBs antibodies in C57/BL6 and BALB/c mice after HI with different concentrations of HBV plasmid DNA

From: The dose of HBV genome contained plasmid has a great impact on HBV persistence in hydrodynamic injection mouse model

 

Anti-HBc (C57/BL6)

Anti-HBs (C57/BL6)

HBV DNA

Day 4

Day 7

Day 10

Day 20

Day 30

5 μg pAAV-HBV1.2

3/10

10/10

0/10

0/10

0/10

10 μg pAAV-HBV1.2

6/10

10/10

0/10

0/10

2/10

100 μg pAAV-HBV1.2

9/10

10/10

0/10

4/10

8/10

 

Anti-HBc (BALB/c)

Anti-HBs (BALB/c)

HBV DNA

Day 4

Day 7

Day 10

Day 20

Day 30

1 μg pAAV-HBV1.2

0/10

10/10

0/10

2/10

4/10

5 μg pAAV-HBV1.2

4/10

10/10

0/10

0/10

2/10

10 μg pAAV-HBV1.2

7/10

10/10

0/10

6/10

10/10

  1. C57/BL6 mice HI with 5 μg, 10 μg or 100 μg pAAV-HBV1.2 plasmid DNA and BALB/c mice injected with 1 μg, 5 μg or 10 μg pAAV-HBV1.2 plasmid DNA separately. The number of animals in each group positive for anti-HBc or anti-HBs antibodies
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Virology Journal

ISSN: 1743-422X