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Fig. 2 | Virology Journal

Fig. 2

From: The dose of HBV genome contained plasmid has a great impact on HBV persistence in hydrodynamic injection mouse model

Fig. 2

HBcAg expression in liver of the C57/BL6 and BALB/c mice after HI with different concentrations of HBV plasmid DNA. 5 μg, 10 μg or 100 μg pAAV-HBV1.2 plasmid DNA were injected into C57/BL6 mice and 1 μg and 5 μg or 10 μg pAAV-HBV1.2 plasmid DNA were injected into BALB/c mice by HI method, separately. At 1, 3, 5, 9, 12 and 24 wpi, mice were sacrificed and livers were analyzed. Immunohistochemical staining of the liver sections for HBcAg in hepatocytes and frequencies of HBcAg positive cells of a C57/BL6 or b BALB/c mice. At least three mice per group were analyzed. The data were analyzed by One-way ANOVA. Statistically significant differences between the different groups were indicated (*means p < 0.05, **means p < 0.01 and ***means p < 0.001)

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Virology Journal

ISSN: 1743-422X