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Table 3 Associations between HLA-DP variants with the detection of OBI

From: Genetic polymorphisms of HLA-DP and isolated anti-HBc are important subsets of occult hepatitis B infection in Indonesian blood donors: a case-control study

Gene, chromosome positiona, allele (major/minor)

SNPs IDb

NON-OBI

MAF (%)

OBI

MAF (%)

Testing of mode of inheritance

NON-OBI vs OBI

Genotype frequency (%)

Genotype frequency (%)

P-valuec

OR (95%CI)d

CC/GG

CT/GA

TT/AA

CC/GG

CT/GA

TT/AA

HLA-DPA1, 33,033,022, C/T

rs3077

43 (41)

53 (51)

8 (8)

33

2 (12)

10 (59)

5 (29)

59

Additive (2 T/T-C/T vs C/C)

0.0015

3.87 (1.58–9.49)

Dominant (C/C vs C/T-T/T)

0.0067

6.12 (1.30–28.85)

Recessive (C/C-C/T vs T/T)

0.016

5.56 (1.45–21.29)

HLA-DPB1, 33,045,558, G/A

rs3135021

54 (53)

37 (37)

10 (10)

28

9 (53)

7 (41)

1 (6)

26

Additive (2A/A-G/A vs G/G)

0.8

0.90 (0.41–2.01)

Dominant (G/G vs G/A-A/A)

0.99

1.01 (0.35–2.87)

Recessive (G/G-G/A vs A/A)

0.54

0.54 (0.06–4.53)

HLA-DPB1, 33,054,861, G/A

rs9277535

39 (38)

50 (48)

15 (14)

38

4 (24)

11 (65)

2 (12)

44

Additive (2A/A-G/A vs G/G)

0.56

1.26 (0.58–2.72)

Dominant (G/G vs G/A-A/A)

0.28

1.89 (0.57–6.33)

Recessive (G/G-G/A vs A/A)

0.76

0.79 (0.16–3.89)

HLA-DPB1, 33,060,118, C/T

rs2281388

70 (67)

24 (23)

11 (1)

22

13 (76)

3 (18)

1 (6)

15

Additive (2 T/T-C/T vs C/C)

rs2281388 deviated from Hardy–Weinberg Equilibrium because the genotype distribution was skewed

Dominant (C/C vs C/T-T/T)

Recessive (C/C-C/T vs T/T)

  1. a,b: SNP identification numbers and positions (http://www.ncbi.nlm.nih.gov/) based on Human Genome Assembly build GRCh37.p17;. c,d: Logistic regression analyses were adjusted for gender and age. Bold values indicate statistically significant