Fig. 4

Alignment of the nucleotide sequences of the current isolates with the reference sequences from the GenBank that encode the carboxyl (C) terminal 19–20 residues of LHDAg showing the clathrin box-binding (CBD) domain and the isoprenylation signal (Py) site nucleotide substitutions variations (a), and the RNA editing targets of the anti-genomic HDV RNA (nt 1012) and its corresponding genomic RNA (nt 580) (b). The amino acid residues that constitute the CBD domain and the Py signal indicated above the nucleotide sequence in a single-letter amino acid abbreviation. Nucleotides positions of RNA editing targets are according to reference strain with accession number X04451