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Fig. 4 | Virology Journal

Fig. 4

From: Prevalence of human pegivirus-1 and sequence variability of its E2 glycoprotein estimated from screening donors of fetal stem cell-containing material

Fig. 4

Sequenced fragment of the E2 glycoprotein. Shannon entropy and dN/dS (ordinate) profiles along the translation of the sequenced fragment are presented. Abscissa: amino acid (aa) position in the E2 protein sequence as per genotype 2a reference sequence (GenBank # D90600). Horizontal bars below the plot display epitopes suggested by earlier studies (refs. in text). Highly variable positions are shown in bold in sequences of the context motifs. These amino acids are also shown above the corresponding peaks of the entropy profile. Predicted secondary structure elements are shown under the motif sequences as follows: ee...e – extended strand, hh…h – alpha helix. Membrane fusion peptide is underlined. HIV-inhibitory peptide is italicized. Glycosylation site is circled. Dumbbell-shaped bar indicates palmitoylation site

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Virology Journal

ISSN: 1743-422X