TY - JOUR AU - Van der Gucht, Winke AU - Leemans, Annelies AU - De Schryver, Marjorie AU - Heykers, Annick AU - Caljon, Guy AU - Maes, Louis AU - Cos, Paul AU - Delputte, Peter L. PY - 2017 DA - 2017/08/17 TI - Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection JO - Virology Journal SP - 157 VL - 14 IS - 1 AB - Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. Therefore, these cellular proteases are putative targets for the development of antivirals that inhibit their activity. Host proteases have been described to play essential roles in Ebola, HCV, HIV and influenza, such that specific protease inhibitors are able to reduce infection. RSV utilizes a host protease in its replication cycle but its potential as antiviral target is unknown. Therefore, we evaluated the effect of protease inhibitors on RSV infection. SN - 1743-422X UR - https://doi.org/10.1186/s12985-017-0824-3 DO - 10.1186/s12985-017-0824-3 ID - Van der Gucht2017 ER -