Chikungunya virus infection in Cynomolgus macaques following Intradermal and aerosol exposure

Table 2 Summary of CHIKV viremia results

Group	Challenge	Infectious Dose	Day 2 (Log₁₀ PFU/mL)		Day 4 (Log₁₀ PFU/mL)		Day 6 (Log₁₀ PFU/mL)
Group	Challenge	Infectious Dose	Titer	Average	Titer	Average	Titer	Average
1	Intradermal	10³	5.93	6.37	3.06	2.96	<2.48^a	<2.48^a
1	Intradermal	10³	6.80	6.37	2.86	2.96	<2.48^a	<2.48^a
2	Intradermal	10⁵	4.75	5.27	<2.48^a	<2.48^a	<2.48^a	<2.48^a
2	Intradermal	10⁵	5.78	5.27	<2.48^a	<2.48^a	<2.48^a	<2.48^a
3	Intradermal	10⁷	5.15	5.30	<2.48^a	<2.48^a	<2.48^a	<2.48^a
3	Intradermal	10⁷	5.44	5.30	<2.48^a	<2.48^a	<2.48^a	<2.48^a
4	Aerosol	10⁴	5.23	5.25	3.60	3.80^b	<2.48^a	<2.48^a
4	Aerosol	10⁴	5.26	5.25	4.00	3.80^b	<2.48^a	<2.48^a
5	Aerosol	10⁶	3.81	3.38^c	3.12	2.81	<2.48^a	<2.48^a
			2.67		2.88		<2.48^a
			<2.48^a		2.60		<2.48^a
			3.67		2.65		<2.48^a

^aPlaque assay Lower Limit of Quantification = 2.48 log₁₀ PFU/mL
^bSignificantly higher than all other groups at this timepoint at the 0.05 level
^cSignificantly lower than all other groups at this timepoint at the 0.05 level

ISSN: 1743-422X