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Fig. 2 | Virology Journal

Fig. 2

From: Expression pattern of CD11c on lung immune cells after disseminated murine cytomegalovirus infection

Fig. 2

Production of CD11cint cells in MCMV-infected lungs. a Dot-plots of lung samples isolated from control, LPS and MCMV groups at 7 days post infection (dpi) are shown. Relative expression of CD11c (X axis) and CD86 (Y axis) is depicted. Cells inside the circles represent the CD11cint population, with low expression of CD86. Histogram of CD11c within each group is shown in the substratum. Both control and LPS groups show two cell populations (CD11clo and CD11chi), while MCMV group shows an extra population of CD11cint cells. b The percentage of CD11cint cells in control, LPS, MCMV and LPS + MCMV groups at 1, 3 and 7 dpi is shown (n = 4 mice/group at each time point, results are representative of four independent experiments). Graphs represent mean ± SD. * P < 0.05 compared to controls; P < 0.05 compared to LPS. c. Dot-plots of lung samples isolated from control, LPS and MCMV groups at 7 dpi are shown, comparing the expression of CD11c (X axis) and MHC II (Y axis). The cells in the rectangles represent the expanded CD11cint population. d Histograms of cell surface MHC II expression in the CD11cint population in each group at 7 dpi are shown. The expansion of the CD11cint population in MCMV group is mainly due to an increase in the proportion of MHC IIlo cells

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