Fig. 2

Production of CD11c^int cells in MCMV-infected lungs. a Dot-plots of lung samples isolated from control, LPS and MCMV groups at 7 days post infection (dpi) are shown. Relative expression of CD11c (X axis) and CD86 (Y axis) is depicted. Cells inside the circles represent the CD11c^int population, with low expression of CD86. Histogram of CD11c within each group is shown in the substratum. Both control and LPS groups show two cell populations (CD11c^lo and CD11c^hi), while MCMV group shows an extra population of CD11c^int cells. b The percentage of CD11c^int cells in control, LPS, MCMV and LPS + MCMV groups at 1, 3 and 7 dpi is shown (n = 4 mice/group at each time point, results are representative of four independent experiments). Graphs represent mean ± SD. * P < 0.05 compared to controls; ☆ P < 0.05 compared to LPS. c. Dot-plots of lung samples isolated from control, LPS and MCMV groups at 7 dpi are shown, comparing the expression of CD11c (X axis) and MHC II (Y axis). The cells in the rectangles represent the expanded CD11c^int population. d Histograms of cell surface MHC II expression in the CD11c^int population in each group at 7 dpi are shown. The expansion of the CD11c^int population in MCMV group is mainly due to an increase in the proportion of MHC II^lo cells