Table 1 Key amino-acid changes in the full genome of JX14737 virus isolated from air samples

PB2

292 V

Increases polymerase activity in 293 T cells

588 V

Enhanced polymerase activity and viral replication in human NHBE cells

HA

Q226L^a

Increased viral binding to α2,6-sialic acid receptor, airborne transmission between mammals

N/K137A^a

Avian-like receptor binding preference (N/137 K)