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Table 1 Cytotoxicity, antiviral activity, and selectivity indexes of 6MMPr and RIB

From: 6-methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro

Compounds Cytotoxicity CC50 (μM)a Antiviral activity
   EC50 (μM)a SIb Log10 reduction valued
     CC20 (μM)c qRT-PCR TCID50
6MMPr 1409 28.7 49.1 338 1.3 >2.2
RIB 424 52 8.2 81.5 0.4 0.6
  1. aCC50 (50% cytotoxic concentration) and EC50 (50% cytotoxic concentration) mean values
  2. bSelectivity index (CC50/EC50)
  3. cCC20 (20% cytotoxic concentration): maximum non-toxic concentration employed in the antiviral assays
  4. dLog10 reduction was calculated by subtracting the log10 means of the CDV infectivity in the presence of CC20 compounds from the log10 means of the CDV infectivity in the untreated cells