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Table 1 Cytotoxicity, antiviral activity, and selectivity indexes of 6MMPr and RIB

From: 6-methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro

Compounds

Cytotoxicity

CC50 (μM)a

Antiviral activity

  

EC50 (μM)a

SIb

Log10 reduction valued

    

CC20 (μM)c

qRT-PCR

TCID50

6MMPr

1409

28.7

49.1

338

1.3

>2.2

RIB

424

52

8.2

81.5

0.4

0.6

  1. aCC50 (50% cytotoxic concentration) and EC50 (50% cytotoxic concentration) mean values
  2. bSelectivity index (CC50/EC50)
  3. cCC20 (20% cytotoxic concentration): maximum non-toxic concentration employed in the antiviral assays
  4. dLog10 reduction was calculated by subtracting the log10 means of the CDV infectivity in the presence of CC20 compounds from the log10 means of the CDV infectivity in the untreated cells
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Virology Journal

ISSN: 1743-422X