Fig. 1

Therapy failure of a patient with HCV GT3a infection treated with SOF/DCV for 12 weeks. a HCV viral load (black line), time of treatment (gray box) and plasma drug levels for DCV (white bar) and the SOF metabolite GS-331007 (black bar) are shown. b Frequency of the RAS NS5A-Y93H and NS5B-S282T at baseline (BL), end of treatment (week 12) and follow-up (FU). c Codon usage at NS5B position 282 as determined by ultra-deep sequencing