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Table 4 Prediction of nsp1 to nsp16 and the cleavage sites of polyproteins 1a and 1b of the AcCoV-JC34

From: Detection of alpha- and betacoronaviruses in rodents from Yunnan, China

nsp

First-last amino acid residues

Protein size (aa)

Cleavage site

Putative functional domain(s)

nsp1

M1-G218

218

SCPCG|KSAFT

Unknown

nsp2

K219-G820

602

WVCKCG|AEVQLS

Unknown

nsp3

A821-A2277

1457

TRVGTA|DLAVFN

ADRP, PL1pro, PL2pro

nsp4

D2278-Q2779

502

LNAQ|SCAK

Hydrophobic domain

nsp5

S2780-Q3042

263

AKVQ|IEGA

3CLpro

nsp6

I3043-Q3319

277

SGMQ|CSWA

Hydrophobic domain

nsp7

C3320-Q3437

118

STIQ|SKLT

Unknown

nsp8

S3438-Q3715

278

VKLQ|NNEI

Unknown

nsp9

N3716-Q3820

105

VRLQ|AGKP

Unknown

nsp10

A3821-Q3955

135

STVQ|SNII

Unknown

nsp11

S3956-N3974

19

-

Short peptide at the end of ORF1a

nsp12

L3956-Q4881

926

SVLQ|SAGL

RdRp

nsp13

S4882-Q5478

597

TDLQ|SVLS

Hel

nsp14

S5479-Q5998

520

PILQ|GLEN

ExoN

nsp15

G5999-Q6334

346

PQLQ|NSEW

NendoU

nsp16

N6345-K6646

302

-

O-MT

  1. Superscript numbers indicate positions in polyprotein pp1ab, with the supposition of a ribosomal frame shift resulting in a peptide bond between N3974/L3975 for the expression of ORF1ab