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Fig. 2 | Virology Journal

Fig. 2

From: Virology analysis in HCV genotype 1-infected patients treated with the combination of simeprevir and TMC647055/ritonavir, with and without ribavirin, and JNJ-56914845

Fig. 2

Prevalence of NS3 (a), NS5B (b) and NS5A (c) baseline polymorphisms in study TMC647055HPC2001. aFC in EC50 values compared with GT1b wild-type replicon assessed as SDM in a transient replicon assay. bSDM in GT1b replicon backbone. cSDM in GT1a replicon backbone. dSDM data for single Y93C. Baseline NS3 sequencing data were not available for 1 patient (HCV GT1l-infected patient); baseline NS5B and NS5A sequencing data were not available for 2 of the evaluable patients (HCV GT1l-infected patient and HCV GT1c-infected patient). EC50: 50% effective concentration; FC: fold change; GT: genotype; NAP: not applicable; ND: not determined; SDM: site-directed mutant; SMV: simeprevir

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Virology Journal

ISSN: 1743-422X