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Table 2 FMDV-Mut tissue distribution

From: Pathogenesis of virulent and attenuated foot-and-mouth disease virus in cattle

Time point (hpi)

24

48

72

Animal ID

699

9106

9107

1003

1024

1035

Clinical score

0

0

0

0

0

0

FMDV RNA copies/μl in serum

neg

neg

neg

neg

neg

neg

Tissue sample

      

Oral cavity/oropharynx

 Anterior tongue

-

-

-

-

-

-

 Lingual tonsil

-

-

-

-

3.15

-

 Anterior hard palate

NA

-

-

-

-

-

 Palatine tonsil

NA

-

-

-

3.14

-

 Ventral soft palate-Caudal

-

-

-

-

3.87

-

Nasal cavity/Nasopharynx

 Nasal turbinates-posterior

-

-

-

-

-

-

 Dorsal soft palate -Rostral

+

2.85

3.16

-

3.73

-

 Dorsal soft palate -Caudal

2.68

4.74

4.15

2.83

4.38

2.95

 Dorsal nasopharynx -Rostral

4.43

-

-

-

3.01

3.07

 Dorsal nasopharynx -Caudal

+

2.57

4.54

-

3.42

3.05

 Nasopharyngeal tonsil

-

-

-

+

-

-

 Ventral epiglottis

-

-

4.31

-

4.10

-

 Larynx

2.70

-

2.75

5.12

3.10

-

Lungs/Trachea

 Trachea −10 cm

-

-

-

-

 

-

 Proximal cranial lobe

NA

-

3.47

4.09

4.79

2.96

 Mid cranial lobe

NA

-

3.86

3.13

2.68

3.91

 Distal cranial lobe

3.36

2.57

+

3.00

4.26

3.98

 Proximal mid lobe

NA

-

3.95

3.22

5.55

3.90

 Mid mid lobe

NA

-

5.56

3.52

4.25

3.92

 Distal mid lobe

3.78

-

3.47

-

3.54

3.22

 Proximal caudal lobe

NA

-

4.99

4.08

4.75

3.73

 Mid caudal lobe

NA

3.49

-

3.40

4.27

-

 Distal caudal lobe

3.62

3.04

3.43

-

3.31

-

Additional tissues

 Interdigital cleft

NA

-

-

-

-

-

 Medial Retropharyngeal LN

NA

-

-

-

+

-

 Submandibular LN

NA

-

-

-

2.57

-

 Hilar LN

NA

-

-

-

2.98

-

  1. Tabulated Numbers indicate FMDV RNA genome copy numbers (GCN) per mg of tissue
  2. Bold and underlined text indicates infectious virus isolated
  3. ‘+’ indicates infectious virus isolated without concurrent detection of FMDV genome
  4. ‘-’ indicates negative for detection of FMDV RNA and infectious virus