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Table 1 FMDV-WT tissue distribution

From: Pathogenesis of virulent and attenuated foot-and-mouth disease virus in cattle

  Pre-viremic Viremic
Time point (hpa) 0.1 3 6 12 24 48 72 96
Animal ID 931 1028 1029 1001 1002 1026 1027 930 927 694 938 960 928 929 9159 962
Clinical score 0 0 0 0 0 0 0 0 0 0 2 6 8 12 4 10
FMDV RNA copies/μl in serum neg neg neg neg neg neg neg neg 1.3 1.5 3.38 3.48 5.88 5.35 4.60 3.53
Tissue sample
Oral cavity/oropharynx
 Anterior tongue 2.81 - - - - - - - - 2.66 2.65 3.38 5.69 6.39 3.90 -
 Lingual tonsil 2.85 - - - - 2.60 - - 4.63 - - 3.64 2.87 4.87 5.26 3.31
 Anterior hard palate 3.06 - - - - - - - - - NA NA 5.30 4.76 3.58 NA
 Palatine tonsil 2.71 - - - - - - - - - 2.83 - 5.20 5.97 4.57 3.09
 Ventral soft palate-Caudal - - - - - 3.49 2.94 3.99 4.80 3.40 - 3.26 4.96 3.86 4.98 4.12
Nasal cavity/Nasopharynx
 Nasal turbinates-posterior 2.97 - - - - - - NA + 3.77 2.61 2.76 2.69 3.01 4.03 2.65
 Dorsal soft palate -Rostral 2.70 3.40 - - 3.91 2.56 - 4.57 3.13 3.28 3.57 4.20 4.08 3.79 3.96 3.84
 Dorsal soft palate -Caudal 3.00 4.39 - - 3.26 4.57 4.61 5.02 5.58 3.36 5.13 3.76 2.92 4.95 4.77 4.52
 Dorsal nasopharynx -Rostral 2.77 3.73 3.97 4.03 3.64 3.80 4.07 5.34 3.11 4.80 5.47 6.07 4.26 4.21 5.39 4.40
 Dorsal nasopharynx -Caudal 2.78 3.61 2.94 - 4.41 3.09 4.25 6.42 4.90 3.85 4.85 3.88 5.16 5.11 4.06 4.84
 Nasopharyngeal tonsil - - - - - - - 3.06 3.58 3.35 3.30 3.43 3.21 2.94 2.94 -
 Ventral epiglottis 3.13 2.80 - - - 4.21 3.05 3.65 4.29 - 3.05 3.07 4.63 5.39 4.48 3.70
 Larynx 2.57 3.00 3.84 - 4.56 3.05 4.26 4.18 3.49 4.20 3.20 3.97 3.41 4.00 4.22 3.31
Lungs/Trachea
 Trachea −10 cm 2.69 - - 3.20 - - 2.70 - - - 3.13 6.37 4.64 2.58 4.09 3.71
 Proximal cranial lobe 2.78 3.69 - - 2.72 3.77 4.26 5.18 3.12 5.35 6.75 7.15 4.82 6.09 5.27 NA
 Mid cranial lobe 3.25 3.14 - 3.87 - 2.65 5.12 3.79 4.59 3.71 7.05 6.65 - 3.69 5.80 NA
 Distal cranial lobe 2.99 4.08 2.69 3.78 - - 5.50 6.10 2.64 5.91 7.25 8.18 3.05 3.48 7.10 NA
 Proximal mid lobe 2.91 3.28 - - - 4.51 4.64 5.72 2.91 5.77 6.13 7.08 5.84 4.73 4.09 5.84
 Mid mid lobe 2.93 3.21 - - - 3.64 4.43 5.21 4.10 5.02 6.56 6.35 4.28 3.78 4.22 6.73
 Distal mid lobe 2.99 4.52 2.86 3.12 3.71 3.72 4.43 6.42 2.74 4.79 7.01 7.99 4.00 3.87 4.21 5.64
 Proximal caudal lobe - NA a NA 3.20 2.52 3.73 4.52 5.67 3.72 4.91 6.29 NA 4.85 5.64 6.19 NA
 Mid caudal lobe - NA NA 4.27 - 4.33 4.79 5.70 3.14 4.16 6.02 NA 2.55 3.62 5.52 NA
 Distal caudal lobe - NA NA 2.71 3.02 - - 4.90 + 5.47 5.49 NA - 2.97 5.53 NA
Additional tissues
 Interdigital cleft - - - - - - - - - NA 2.58 - 6.26 8.97 5.03 9.22
 Medial Retropharyngeal LN - - - - - + + 2.94 + NA 2.97 3.87 4.36 + 3.40 +
 Submandibular LN - - - - - - - - - NA - 4.09 3.24 3.79 4.17 4.01
 Hilar LN - - - - - + + 2.92 - NA 4.80 5.17 2.81 3.23 3.77 3.22
  1. Tabulated Numbers indicate FMDV RNA genome copy numbers (GCN) per mg of tissue
  2. Bold and underlined text indicates infectious virus isolated
  3. ‘+’ indicates infectious virus isolated without concurrent detection of FMDV genome
  4. ‘-’ indicates negative for detection of FMDV RNA and infectious virus
  5. Additional organs collected were liver, spleen, thymus, thyroid, kidneys and heart; there was no detection of FMDV prior to onset of viremia at any of these sites
  6. aNA = not assayed