Table 1 FMDV-WT tissue distribution
From: Pathogenesis of virulent and attenuated foot-and-mouth disease virus in cattle
| Â | Pre-viremic | Viremic | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Time point (hpa) | 0.1 | 3 | 6 | 12 | 24 | 48 | 72 | 96 | ||||||||
Animal ID | 931 | 1028 | 1029 | 1001 | 1002 | 1026 | 1027 | 930 | 927 | 694 | 938 | 960 | 928 | 929 | 9159 | 962 |
Clinical score | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 8 | 12 | 4 | 10 |
FMDV RNA copies/μl in serum | neg | neg | neg | neg | neg | neg | neg | neg | 1.3 | 1.5 | 3.38 | 3.48 | 5.88 | 5.35 | 4.60 | 3.53 |
Tissue sample | ||||||||||||||||
Oral cavity/oropharynx | ||||||||||||||||
 Anterior tongue | 2.81 | - | - | - | - | - | - | - | - | 2.66 | 2.65 | 3.38 | 5.69 | 6.39 | 3.90 | - |
 Lingual tonsil | 2.85 | - | - | - | - | 2.60 | - | - | 4.63 | - | - | 3.64 | 2.87 | 4.87 | 5.26 | 3.31 |
 Anterior hard palate | 3.06 | - | - | - | - | - | - | - | - | - | NA | NA | 5.30 | 4.76 | 3.58 | NA |
 Palatine tonsil | 2.71 | - | - | - | - | - | - | - | - | - | 2.83 | - | 5.20 | 5.97 | 4.57 | 3.09 |
 Ventral soft palate-Caudal | - | - | - | - | - | 3.49 | 2.94 | 3.99 | 4.80 | 3.40 | - | 3.26 | 4.96 | 3.86 | 4.98 | 4.12 |
Nasal cavity/Nasopharynx | ||||||||||||||||
 Nasal turbinates-posterior | 2.97 | - | - | - | - | - | - | NA | + | 3.77 | 2.61 | 2.76 | 2.69 | 3.01 | 4.03 | 2.65 |
 Dorsal soft palate -Rostral | 2.70 | 3.40 | - | - | 3.91 | 2.56 | - | 4.57 | 3.13 | 3.28 | 3.57 | 4.20 | 4.08 | 3.79 | 3.96 | 3.84 |
 Dorsal soft palate -Caudal | 3.00 | 4.39 | - | - | 3.26 | 4.57 | 4.61 | 5.02 | 5.58 | 3.36 | 5.13 | 3.76 | 2.92 | 4.95 | 4.77 | 4.52 |
 Dorsal nasopharynx -Rostral | 2.77 | 3.73 | 3.97 | 4.03 | 3.64 | 3.80 | 4.07 | 5.34 | 3.11 | 4.80 | 5.47 | 6.07 | 4.26 | 4.21 | 5.39 | 4.40 |
 Dorsal nasopharynx -Caudal | 2.78 | 3.61 | 2.94 | - | 4.41 | 3.09 | 4.25 | 6.42 | 4.90 | 3.85 | 4.85 | 3.88 | 5.16 | 5.11 | 4.06 | 4.84 |
 Nasopharyngeal tonsil | - | - | - | - | - | - | - | 3.06 | 3.58 | 3.35 | 3.30 | 3.43 | 3.21 | 2.94 | 2.94 | - |
 Ventral epiglottis | 3.13 | 2.80 | - | - | - | 4.21 | 3.05 | 3.65 | 4.29 | - | 3.05 | 3.07 | 4.63 | 5.39 | 4.48 | 3.70 |
 Larynx | 2.57 | 3.00 | 3.84 | - | 4.56 | 3.05 | 4.26 | 4.18 | 3.49 | 4.20 | 3.20 | 3.97 | 3.41 | 4.00 | 4.22 | 3.31 |
Lungs/Trachea | ||||||||||||||||
 Trachea −10 cm | 2.69 | - | - | 3.20 | - | - | 2.70 | - | - | - | 3.13 | 6.37 | 4.64 | 2.58 | 4.09 | 3.71 |
 Proximal cranial lobe | 2.78 | 3.69 | - | - | 2.72 | 3.77 | 4.26 | 5.18 | 3.12 | 5.35 | 6.75 | 7.15 | 4.82 | 6.09 | 5.27 | NA |
 Mid cranial lobe | 3.25 | 3.14 | - | 3.87 | - | 2.65 | 5.12 | 3.79 | 4.59 | 3.71 | 7.05 | 6.65 | - | 3.69 | 5.80 | NA |
 Distal cranial lobe | 2.99 | 4.08 | 2.69 | 3.78 | - | - | 5.50 | 6.10 | 2.64 | 5.91 | 7.25 | 8.18 | 3.05 | 3.48 | 7.10 | NA |
 Proximal mid lobe | 2.91 | 3.28 | - | - | - | 4.51 | 4.64 | 5.72 | 2.91 | 5.77 | 6.13 | 7.08 | 5.84 | 4.73 | 4.09 | 5.84 |
 Mid mid lobe | 2.93 | 3.21 | - | - | - | 3.64 | 4.43 | 5.21 | 4.10 | 5.02 | 6.56 | 6.35 | 4.28 | 3.78 | 4.22 | 6.73 |
 Distal mid lobe | 2.99 | 4.52 | 2.86 | 3.12 | 3.71 | 3.72 | 4.43 | 6.42 | 2.74 | 4.79 | 7.01 | 7.99 | 4.00 | 3.87 | 4.21 | 5.64 |
 Proximal caudal lobe | - | NA a | NA | 3.20 | 2.52 | 3.73 | 4.52 | 5.67 | 3.72 | 4.91 | 6.29 | NA | 4.85 | 5.64 | 6.19 | NA |
 Mid caudal lobe | - | NA | NA | 4.27 | - | 4.33 | 4.79 | 5.70 | 3.14 | 4.16 | 6.02 | NA | 2.55 | 3.62 | 5.52 | NA |
 Distal caudal lobe | - | NA | NA | 2.71 | 3.02 | - | - | 4.90 | + | 5.47 | 5.49 | NA | - | 2.97 | 5.53 | NA |
Additional tissues | ||||||||||||||||
 Interdigital cleft | - | - | - | - | - | - | - | - | - | NA | 2.58 | - | 6.26 | 8.97 | 5.03 | 9.22 |
 Medial Retropharyngeal LN | - | - | - | - | - | + | + | 2.94 | + | NA | 2.97 | 3.87 | 4.36 | + | 3.40 | + |
 Submandibular LN | - | - | - | - | - | - | - | - | - | NA | - | 4.09 | 3.24 | 3.79 | 4.17 | 4.01 |
 Hilar LN | - | - | - | - | - | + | + | 2.92 | - | NA | 4.80 | 5.17 | 2.81 | 3.23 | 3.77 | 3.22 |