Fig. 3
From: Pathogenesis of virulent and attenuated foot-and-mouth disease virus in cattle
Detection of FMDV-WT by immunomicroscopy in bovine nasopharynx at 12 h post aerosol-inoculation. a Cells containing FMDV VP1 antigen (red) are within the cytokeratin-positive epithelium (green). Epithelium overlies an expansive field of mucosa-associated lymphoid tissue with numerous cells containing CD11c (turquoise) and MHCII (purple). Dashed-lined box indicates region of interest (ROI) shown at higher magnification in 3b. b FMDV-containing cells express cytokeratin and are in the superficial-most layer of epithelium. These cells have morphology consistent with acantholytic degeneration including swelling and dissociation from adjacent cells. Multichannel immunofluorescence microcopy, (animal ID 1027, tissue ID Dorsal nasopharynx -Rostral) (magnification: a 10×, b 40×)