Fig. 1

Clinical signs of ZIKV-infected guinea pigs: a Temperature difference in animals compared with baseline taken on the day of infection. *p < 0.05, **p < 0.001. b Clinical score of animals after infection. The designation for the clinical scores is as follows: 1, healthy; 2, mild signs of lethargy; 3, mild signs of lethargy, fur ruffling, hunched posture; 4, increased lethargy, limited mobility, ruffled fur, hunched posture; 5, moribund with minimal mobility and inability to eat food or drink water (n = 3 –9 per time point). *p < 0.05 (compared to the baseline taken on the day of infection). c Weight change depicted as percentage difference compared to the day of infection