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Fig. 5 | Virology Journal

Fig. 5

From: Glucose-regulated protein 78 demonstrates antiviral effects but is more suitable for hepatocellular carcinoma prevention in hepatitis B

Fig. 5

ETV and D6R abolished the enhancing effects of GRP78 down-regulation on HBV replication and HBeAg secretion. HepG2.2.15 cells were regularly cultivated, transfected with siRNA targeted GRP78 (siGRP78) or its control (siControl) and treated with or without ETV (20 nmol/L) or furin inhibitor II (D6R, 100 μmol/L). a ETV abolished the enhancing effect of GRP78 down-regulation on supernatant core-associated HBV DNA. Results are expressed as n-fold times the supernatant HBV DNA level of test groups over those of controls. * P < 0.05, **P < 0.01. b. ETV abolished the enhancing effect of GRP78 down-regulation on intracellular core-associated HBV DNA. Relaxed circular (RC) HBV DNA was the HBV genome, and single stranded (SS) HBV DNA, other bands and the smear were the replication intermediates (RI) of HBV. c Furin inhibitor abolished the enhancing effect of GRP78 down-regulation on HBeAg secretion. Results are expressed as n-fold times the supernatant HBeAg level of test groups over those of controls. * P < 0.05

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Virology Journal

ISSN: 1743-422X