Fig. 4

GRP78 overexpression promoted wound healing in HepG2.2.15 cells. HepG2.2.15 cells were regularly cultivated and transfected with pGRP78 (GRP78-expressing recombinant plasmid generated from pCMV6-XL5) or empty vector, pCMV6-XL5 (pVector). a After transfection, confluent cells were wounded by sterile pipettes and the wound statuses were photographed at the beginning and 48 h after wounded. b Cells with GRP78 overexpression had a significantly higher wound closure ratio. * P < 0.05. c Cell proliferation was examined using MTT analysis. The proliferation statuses of those cells with and without GRP78 overexpression were identical 48 h after wounded