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Fig. 4 | Virology Journal

Fig. 4

From: Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2′, 3′-cGAMP VacciGrade™ adjuvant exacerbates viremia after virus challenge

Fig. 4

Rectal temperature, viremia, and histological lesions of lungs of animal challenged with PRRSV. Top left panel: Averages and standard deviations of rectal temperatures of 6 animals in each group at defined time points after virus challenge. * indicates p < 0.05 between PBS and VLPs & adjuvant group. Top right panel: Averages and standard deviations of Ct values of animals with detectable PRRSV RNA at duplicate qRT-PCR runs. *indicates p < 0.000001 between VLPs + Adjuvant group and PBS group. **indicates p < 0.01 between VLPs and PBS groups. Lower left panel: representative pictures showing the histological lesions of lungs at 10 DPC. Magnification 4×. Lower right panel: Averages and standard deviations of lung lesion scores of individual animals in each group. Scoring of the gross and microscopic lesions was based on the previously published data [11]. 0 = no lesions; 1 = mild interstitial pneumonia; 2 = moderate, multifocal interstitial pneumonia; 3 = moderate diffuse interstitial pneumonia; 4 = severe interstitial pneumonia

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