Table 3 Responses between different rtA181T/sW172 mutations
From: Antiviral efficacy of entecavir for hepatitis B virus rtA181V/T mutants
Characteristics | rtA181T/sW172* mutation group (n = 22) | other missense mutations group (n = 4) | P value |
|---|---|---|---|
Before Rescue | |||
HBV DNA (log10 IU/mL) | |||
Mean ± SD | 4.16 ± 2.35 | 3.61 ± 0.21 | 0.298 |
HBsAg (lg IU/ml) | |||
Mean ± SD | 3.52 ± 0.48 | 3.46 ± 0.40 | 0.795 |
ALT (U/L) | |||
Mean ± SD | 142.5 ± 253.8 | 59.0 ± 40.9 | 0.524 |
After Rescue | |||
HBV DNA Reduction (log10 IU/mL) | |||
6th Month (Mean ± SD) | 3.31 ± 2.25 | 3.61 ± 0.21 | 0.797 |
12th Month (Mean ± SD) | 3.66 ± 2.18 | 3.61 ± 0.21 | 0.918 |
HBsAg (log10 IU/ml) | |||
6th Month (Mean ± SD) | 3.50 ± 0.45 | 3.47 ± 0.42 | 0.908 |
12th Month (Mean ± SD) | 3.31 ± 0.50 | 3.14 ± 0.50 | 0.529 |
ALT (U/L) | |||
6th Month (Mean ± SD) | 39.6 ± 19.3 | 20.5 ± 11.7 | 0.069 |
12th Month (Mean ± SD) | 39.0 ± 20.0 | 23.5 ± 3.1 | 0.142 |