Table 2 Relationship between TLR2, TLR4 and TLR9 SNPs and the occurrence of HCMV infection among pregnant women
From: Toll-like receptors genes polymorphisms and the occurrence of HCMV infection among pregnant women
Gene polymorphism | Genetic model | Genotype | Genotype prevalence rates; n (%) a | ORb (95% CI) c | P-valued | |
|---|---|---|---|---|---|---|
Infected cases | Uninfected controls | |||||
TLR2 2258 G > A | - | GG | 62 (93.9%) | 59 (92.2%) | 1.00 | |
GA | 4 (6.1%) | 5 (7.8%) | 0.76 (0.19–2.97) | 0.690 | ||
TLR4 896 A > G | - | AA | 56 (91.8%) | 53 (86.9%) | 1.00 | |
AG | 5 (8.2%) | 8 (13.1%) | 0.59 (0.18–1.92) | 0.380 | ||
TLR4 1196 C > T | - | CC | 60 (90.9%) | 55 (87.3%) | 1.00 | |
CT | 6 (9.1%) | 8 (12.7%) | 0.69 (0.22–2.11) | 0.510 | ||
TLR9 2848 G > A | Codominant | GG | 8 (13.3%) | 13 (20.3%) | 0.39 (0.13–1.13) | 0.093 |
GA | 25 (41.7%) | 34 (53.1%) | 0.46 (0.21–1.03) | |||
AA | 27 (45.0%) | 17 (26.6%) | 1.00 | |||
Dominant | AA | 27 (45.0%) | 17 (26.6%) | 1.00 | ||
GA-GG | 33 (55.0%) | 47 (73.4%) | 0.44 (0.21–0.94) | 0.032 | ||
Recessive | AA-GA | 52 (86.7%) | 51 (79.7%) | 1.00 | ||
GG | 8 (13.3%) | 13 (20.3%) | 0.60 (0.23–1.58) | 0.300 | ||
Overdominant | GG-AA | 35 (58.3%) | 30 (46.9%) | 1.00 | ||
GA | 25 (41.7%) | 34 (53.1%) | 0.63 (0.31–1.28) | 0.200 | ||