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Fig. 4 | Virology Journal

Fig. 4

From: Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence

Fig. 4

The viral titers in tears of mice inoculated with each virus clone to cornea. Mice were infected with each virus clone at the dose of 1 × 106 PFU through corneal inoculation. Tears were collected every day for 7-day observation period. Viral titer in tears were determined by plaque forming assay in Vero cells. All the mice inoculated with HSV-1 TAS or CL19 died within 6 and 7 days p.i., respectively

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