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Table 3 Inhibitory activity of N30 against different strains of Cosackie B virus

From: A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5’-Monophospate Dehydrogenase activity

Strain

N30

RBV

TC50 (μM)

IC50 (μM)

SI

TC50 (mM)

IC50 (mM)

SI

CVB1

89.56 ± 4.25

6.28 ± 1.61

14.26

>20.00

2.37 ± 0.36

>8.44

CVB2

89.56 ± 4.25

11.65 ± 2.94

7.69

>20.00

2.27 ± 0.18

>8.81

CVB3

89.56 ± 4.25

1.82 ± 2.76

49.21

>20.00

3.13 ± 1.21

>6.39

CVB4

89.56 ± 4.25

10.37 ± 3.13

8.64

>20.00

2.47 ± 1.60

>8.10

CVB5

89.56 ± 4.25

2.54 ± 1.43

35.26

>20.00

1.20 ± 0.53

>16.67

CVB6

89.56 ± 4.25

6.81 ± 1.89

13.15

>20.00

4.56 ± 2.41

>4.39