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Table 2 Inhibitory activity of N30 against eight influenza strains

From: A novel benzo-heterocyclic amine derivative N30 inhibits influenza virus replication by depression of Inosine-5’-Monophospate Dehydrogenase activity

Strain N30 RBV OC AH
IC50(μM) SI IC50(μM) SI IC50(μM) SI IC50(μM) SI
A/FortMonmouth/1/1947 1.93 ± 0.16 34.54 1.64 ± 0.72 >121.95 0.25 ± 0.01 >200 0.65 ± 0.59 >307.69
A/tianjinjinnan/15/2009 1.67 ± 0.49 39.92 2.54 ± 1.25 >78.74 2.57 ± 0.10 >19.45 18.24 ± 0.24 >10.96
A/liaoningzhenxing/1109/2010 3.43 ± 3.36 19.44 4.92 ± 3.02 >40.65 3.20 ± 0.21 >15.58 10.13 ± 0.04 >19.74
A/wuhan/359/1995 1.31 ± 0.87 50.89 8.23 ± 6.31 >24.30 0.12 ± 0.01 >416.67 15.64 ± 0.31 >12.78
A/fujiantongan/196/2009 1.13 ± 0.43 59.00 4.42 ± 0.74 >45.25 0.28 ± 0.01 >178.57 78.84 ± 3.04 >2.54
A/hunanzhuhui/1222/2010 1.76 ± 0.24 37.89 2.34 ± 0.98 >85.47 0.78 ± 0.02 >64.10 57.24 ± 2.23 >3.49
BV/shenzhen/155/2005 1.16 ± 0.69 57.47 1.70 ± 0.57 >117.65 1.02 ± 0.08 >49.02 >200 -
BY/fujianxinluo/54/2006 0.70 ± 0.18 95.24 2.48 ± 0.53 >80.65 0.56 ± 0.02 >89.28 >200 -
  1. Note: The TC50 of N30, OC, RBV and Amantadine were 66.67 μM, >50 μM, >200 μM, >200 μM, respectively
  2. “−”: no antiviral activity at the maximal nontoxic concentration