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Table 4 Average PNGs per isolate for each subtype, nucleic acid source and viral tropism

From: Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART

 

Mean PNGs, Number of isolates; % of n

Number of isolates, (% of Total)

All Patterns

NXT Pattern

NXS Pattern

NNX (S) T Pattern

Subtype

Subtype A1, n = 36 (65.4)

11.11, 36; 100

7.19, 36; 100

3.78, 36; 100

0.14, 4; 11.1

A1r recombinants n = 5 (9.1)

10.80, 5; 100

6.80, 5; 100

3.80, 5; 100

0.20, 1; 20

Subtype A2, n = 4 (7.3)

10.75, 4; 100

7.75, 4; 100

3, 4; 100

0, 0; 0

Subtype C, n = 5 (9.1)

11.2, 5; 100

7.4, 5; 100

3.8, 5; 100

0, 0; 0

Subtype D, n = 5 (9.1)

12.4, 5; 100

8.4, 5; 100

3.8, 5; 100

0.2, 1; 20

Tropism

CCR5, n = 42 (76.4)

11.02, 42; 100

7.21, 42; 100

3.64, 42; 100

0.17, 5; 100

CXCR4, n = 13 (23.6)

11.69, 13; 100

7.69, 13; 100

4, 13; 100

0

Nucleic Acid Source

DNA, n = 40 (72.7)

11.6 a, 40; 100

7.68 a, 40; 100

3.85, 40; 100

0.08, 2; 5

RNA, n = 15 (27.3)

10.07 a, 15; 100

6.4 a, 15; 100

3.4, 15; 100

0.27, 3; 20

Total, n = 55 (100)

11.18, 55; 100

7.33, 55; 100

3.73, 55; 100

0.13, 5; 9.1

  1. Key: A1R: recombinants of A1 (A1A2, n = 1; A1D, n = 3;& A1A2D, n = 1); aSignificantly different between DNA (cellular) and (RNA) extracellular viral isolates for the NXT (p = 0.016), and for all the patterns combined (p = 0.011)