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Table 3 The distribution and clustering of specific amino acid PNG sites according to viral tropism and source material

From: Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART

Number of isolates; % possessing the shown amino acid PNG at specified site
  N262 N277 N296 N302 N337 N345 N366 N399 N408 Total
NA source
DNA 33; 82.5 40; 100 28; 70 39;97.5 25;62.5 30; 75 32; 80 35;87.5 33; 82.5 40; 100
RNA 11; 73.3 14;93.3 10;66.7 15; 100 8; 53.3 10;66.7 9; 60 8; 53.3 7; 46.7 15; 100
Tropism
CCR5 31; 73.8 41;97.6 29;69.0 41;97.6 25;59.5 30;71.4 33;78.6 31;73.8 29; 69.0 42; 100
CXCR4 13; 100 13;100 9; 69.2 13;100 8; 61.5 10;76.9 8; 61.5 12;92.3 11; 84.6 13; 100
Subtype
A1 28; 77.8 36; 100 24; 66.7 36; 100 18; 50 27; 0.75 30; 83.3 25; 69.4 26; 72.2 36; 100
A1ra 4; 80 4; 80 5; 100 5; 100 4; 80 3; 60 2; 40 4; 80 3; 60 5; 100
A2 3;75 4;100 4;100 4;100 3;75 2;50 3;75 4;100 2;50 4;100
C 4;80 5;100 1;20 4;80 4;80 3;60 5;100 5;100 4;80 5;100
D 5;100 5;100 4;80 5;100 4;80 5;100 1;20 5;100 5;100 5;100
Overall 44; 80 54;98.2 38;69.1 54;98.2 33; 60 40;72.7 41;74.5 43;78.2 40; 72.7 55;100
  1. Key: NA Nucleic Acid. Tropism analysis is based on false positive rate of 10%. aA1r; A1A2 (n = 1), A1D (n = 3), and A1A2D (n = 1). Mean PNG differences are significant between subtypes at specific A.A positions N277 (p = 0.034), N296 (p = 0.036), N302 (p = 0.034) and N366 (p = 0.004) in Anova tests