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Table 1 NP amino acid substitution analysis

From: Identification of influenza A nucleoprotein body domain residues essential for viral RNA expression expose antiviral target

NP domain targeted

NP amino acid

vRNP activity

NPrbp1 – RNA binding pocket

R152A

YES

NPbd1 – body domain

E46A, K48A

YES

NPbd2 – body domain

D101A

YES

NPbd3 – body domain

Y289G, K293G, E294G, Q308G, N309G

NO

NPbd4 – body domain

S482A

YES

NPbd5 – body domain

S467G, E469G, N470G, T471G, N472G

YES

NPhd1 – head domain

R213A, K214A

YES

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Virology Journal

ISSN: 1743-422X