Fig. 5From: Dendritic cells, macrophages, NK and CD8+ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme BEarlier type I IFN expression in the lung occurs in WT infected animals. Mice were infected with 106 p.f.u. of HSV-1, euthanized, and lung tissues were collected for mRNAs expression analysis by qPCR. IFN-β (a) and IFN-α4 (b) mRNAs level in the lung 3 or 24 h after infection. Mock-infected = animals that inhaled PBS. The results use arbitrary units for the ratio of target gene mRNA to endogenous control HPRT mRNA. Data are representative of two independent experiments with similar results. KO = TLR2/9−/− mice. Bars show the means ± SEM. * p < 0.05; ** p < 0.01 and *** p < 0.001. n = 7–11 mice/groupBack to article page