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Fig. 3 | Virology Journal

Fig. 3

From: Dendritic cells, macrophages, NK and CD8+ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B

Fig. 3

Monocytes/macrophages are the main iNOS producers in the TG of C57BL/6 mice during HSV-1 infection. Groups of six mice were infected with 106 p.f.u. HSV-1 via the intranasal route and, on the 5th day post infection, mice were euthanized, and TG and spleen cell suspensions prepared for cytometry analyses. a Frequencies of iNOS-producing myeloid cell populations (CD45+CD3−CD11b+) within the live leukocyte population. b Frequencies of iNOS-producing monocytes/macrophages (Mo/Mϕ) (CD45+F4/80+) within the population of live leukocytes in the TG and spleen. A minimum of 100,000 events was acquired for analysis. KO = TLR2/9−/− mice. White bars: mock-infected mice; black bars: infected mice. Bars show the means ± SEM. * p < 0.05; ** p < 0.01 and *** p < 0.001

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Virology Journal

ISSN: 1743-422X