Fig. 6
Histopathology following exposure to aerosolized EEEV. a Examination of the frontal cortex of the brain revealed the presence of multifocal meningoencephalitis with hemorrhage (HE; magnification, 4×). b Blood vessel in frontal cortex displayed vasculitis with perivascular hemorrhage (arrow) (HE; magnification, 20×). c In the corpus striatum, two neurons (arrows) showed hypereosinophilic perikaryon (cytoplasm) suggesting necrosis. Vasculitis (V) with perivascular hemorrhage was seen in an adjacent vessel and gliosis (asterisk) in the surrounding neuropil (HE; magnification, 40×). d In the pons, three centrally located neurons (arrows) were observed that were shrunken and angular with hypereosinophilic perikaryon and deeply basophilic (hyperchromatic) nuclei (HE; magnification, 60×). Images are from marmoset #4 exposed to 9.76 × 104 PFU of EEEV