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Fig. 4 | Virology Journal

Fig. 4

From: Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy

Fig. 4

BBR could inhibit EV71-induced autophagy. (a, b) BBR but not pirodavir can reduce EV71-induced autophagy. Vero cells were mock-infected or infected with EV71 (H, MOI = 0.1) for 1 h. The cells were then treated with BBR (40 μmol/L) and pirodavir (0.5 μmol/L), respectively, for 24 h. The cells were harvested and proteins were examined by western blot. (c) BBR and 3-MA could both reduce EV71 infection by inhibiting autophagy. Vero cells were mock-infected or infected with EV71 (H, MOI = 0.1) for 1 h. The cells were then treated with BBR (40 μmol/L) and 3-MA (5 μmol/L), respectively, for 24 h. The cells were harvested and proteins were examined by western blot

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