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Table 2 List of pathways upregulated and downregulated between selected, persistently infected, and naïve BA3NI ciPSCs

From: Derivation of chicken induced pluripotent stem cells tolerant to Newcastle disease virus-induced lysis through multiple rounds of infection

BA3NI-I9-C1 compared to BA3NI-I0 BA3NI-I6 compared to BA3NI-I9-C1 BA3NI-I6 compared to BA3NI-I0
Upregulated Downregulated Upregulated Downregulated Upregulated Downregulated
Al, ASP, GLU Metabolism Fatty Acid Elongation Fatty Acid Elongation Al, ASP, GLU Metabolism   Ribosome Biogenesis in Eukaryotes
Val, Leu, Iso degradation Steroid Hormone Biosynthesis Steroid Hormone Biosynthesis Lysine degradation   Spliceosome
Lysine degradation Oxidative Phosphorylation Oxidative Phosphorylation Inositol Phosphate Metabolism   
Inositol Phosphate Metabolism Pyrimidine Metabolism Pyrimidine Metabolism mRNA surveillance Pathway   
MAPK Signalling Pathway Glutathione Metabolism Arginin and Proline Metabolism MAPK Signalling Pathway   
ERBB Signalling Pathway N-Glycan Biosynthesis Tyrosine Metabolism ERBB Signalling Pathway   
FOXO Signalling Pathway GPI-anchor Biosynthesis Glutathione Metabolism FOXO Signalling Pathway   
PI Signalling System Ribosome Biogenesis in Eukaryotes N-Glycan Biosynthesis PI Signalling System   
Oocyte Meiosis Ribosome Glycosaminoglycan Degradation Oocyte Meiosis   
Ubiquitin-Mediated Proteolysis RNA polymerase GPI Anchor Biosynthesis Ubiquitin-Mediated Proteolysis   
Endocytosis Spliceosome Arachidonic Acid and Metabolism Endocytosis   
mTOR signalling Pathway Proteasome Metabolism of Xenobiotics by Cytochrome P450 mTOR Signalling Pathway   
Apoptosis Protein Export Ribosome Apoptosis   
Adrenergic signalling in Cardiomyocytes Neuroactive ligand-receptor interaction Proteasome Adrenergic signalling in Cardiomyocytes   
Vascular smooth muscle contraction Protein Processing in Endoplasmic Reticulum Protein Export Vascular smooth muscle contraction   
WNT Signalling Pathway Lysosome Neuroactive Ligand-Receptor Interaction WNT Signalling Pathway   
Dorso-Ventral Axis Formation Phagosome Protein Processing in Endoplasmic reticulum Dorso-Ventral Axis Formation   
VEGF Signalling Pathway Cardiac Muscle Contraction Lysosome VEGF Signalling Pathway   
Focal Adhesion Cell Adhesion Molecules Cardiac Muscle Contraction Focal Adhesion   
Tight Junction   Cell Adhesion Molecules Adherens Junction   
Gap Junction    Tight Junction   
Regulation of Actin Cytoskeleton    Gap Junction   
Insulin Signalling Pathway    Toll-like receptor Signalling pathway   
GnRH Signalling Pathway    Jak-Stat Signalling pathway   
Progesterone-mediated Oocyte maturation    Regulation of Actin Cytoskeleton   
    Insulin Signalling pathway   
    GnRH Signalling Pathway   
    Progesterone-Mediated Oocyte Maturation   
    Salmonella Infection   
    Influenza A infection