Skip to main content
Fig. 5 | Virology Journal

Fig. 5

From: Derivation of chicken induced pluripotent stem cells tolerant to Newcastle disease virus-induced lysis through multiple rounds of infection

Fig. 5

Repeated NDV selection decreases susceptibility of ciPSC to NDV-induced cell death. Progression of tolerance to rLS-RFP challenge (MOI = 50) between different rounds of infection (round 3, I3; round 6, I6; round 9, I9). C1 and C2 indicate the two clones sorted from the persistently infected cells (I6-PI). Survival data were obtained by normalizing to the basal level of tolerance of naïve cells (n values, see material and methods). BA3NI-I3, I6 and I9 showed increased tolerance with progressive rounds of infection, compared to never-infected BA3NI-I0 (level 0). For BA3NI-I9-C1 and C2, n = 9; for the other groups, n = 3. n values are expressed as mean ± SD. Letters indicate significant differences between groups (Kruskal-Wallis and Dunn’s method for multiple comparisons, p < 0.05)

Back to article page

Virology Journal

ISSN: 1743-422X